Effect of Polymer-Based Nanoparticles on the Assay of Antimicrobial Drug Delivery Systems

At the present time, infectious diseases maintain the importance among the reasons of deaths in the world. The main reasons of this situation are the antibiotic resistance of bacteria and the chemical limitations on synthesis of the new antibiotic molecules. To overcome these restrictions, effective drug delivery strategies like polymeric micelles, liposomes, dendrimers, solid–lipid nanoparticles keep its novelty by different scientist. Among these delivery systems, polymer-based nanoparticles have gained much attention because they provide to target the antibiotic agents to infectious regions, and have high stability in the biological environment. From this perspective, polymer-based nanosized systems can present a promising approach for the treatment of bacterial infections and be an effective strategy to overcome the serious problems. This chapter underlines the effectiveness and in vitro/in vivo performance of various antibiotics encapsulated polymer-based nanoparticles in the treatment of infectious diseases. A collection of published papers is summarized from this perspective and comments in terms of target microorganism, advantage and activity of the developed delivery system, properties of analytical techniques for the determination of in vitro and in vivo samples with the validation parameters.