钆
生物相容性
纳米颗粒
生物相容性材料
磁共振造影剂
化学
磁共振成像
纳米技术
转铁蛋白
材料科学
生物医学工程
核磁共振
作者
Yang Zhao,Jing Peng,Jingjin Li,Ling Huang,Jingyi Yang,Kai Huang,Li Hewen,Ning Jiang,Shaokuan Zheng,Xuening Zhang,Niu Yuanjie,Gang Han
出处
期刊:Nano Letters
[American Chemical Society]
日期:2017-06-26
卷期号:17 (7): 4096-4100
被引量:47
标识
DOI:10.1021/acs.nanolett.7b00828
摘要
Biocompatibility, targeting, and clearance are key challenges in the design of new MRI contrast agents. Herein, we report on a tumor-targeting, gadolinium biomineralized human transferrin (Tf) protein-based nanoparticle (Gd@Tf NP) for MRI use. As compared to the conventionally used gadolinium chelates, the resultant Gd@Tf NPs possess outstanding chemical stability and exhibited superior longitudinal relaxation. More importantly, our MR images show that Gd@Tf indeed retained the natural tumor targeting ability and the subsequent tumor retrieval biofunctions of Tf. Thus, such Tf protein-based MR NPs integrate T1 signal amplification, precise tumor targeting, and systematic clearance capabilities. They offer a new approach to design biocompatible multifunctional MRI contrast agents for a wide range of clinical imaging and treatment applications.
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