抗体
免疫系统
溶解循环
葡聚糖
脾脏
免疫学
生物
免疫
淋巴细胞
细胞
体外
分子生物学
生物化学
病毒
酶
作者
I. C. M. MacLennan,G. Loewi,Brian Harding
出处
期刊:PubMed
日期:1970-03-01
卷期号:18 (3): 397-404
被引量:59
摘要
Rats were immunized by intraperitoneal injection of target cells (Chang cells). Five days after immunization antibody, lytic to Chang cells in the presence of complement, which separated in Peak I on Sephadex G-150 was detectable. At the same time antibody lytic to Chang cells in the presence of lymphoid cells from unimmunized animals and separating in Peak II on Sephadex G-150 was found. Both antibodies reached a maximum titre between 2 and 4 weeks after immunization. At that time the antibody dependent upon normal lymphoid effector cells was active at more than 1000 times the maximal dilution of complement dependent antibody activity. The Peak II antibody affected both im-immune and non-immune Black Hooded (BH) rat spleen cells in a similar way. Normal rat serum markedly enhanced target cell survival. This effect did not require heat labile components of complement. The enhancing capacity of immune serum appears to be greater than that of normal serum; the reason for this is discussed, but the problem is not resolved.
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