Advances in Fenton reaction-mediated ferroptosis for enhanced cancer therapy: mechanisms, amplification strategies, and synergistic approaches

systems. Furthermore, we discuss synergistic therapies integrating ferroptosis with chemotherapy, radiotherapy, photothermal and photodynamic therapy, gas therapy, and immunotherapy to overcome resistance and promote immunogenic cell death. Emerging designs exploit tumor-specific features such as acidic pH, high peroxide flux, and aberrant iron metabolism to achieve spatially confined oxidative lethality with minimal systemic toxicity. Collectively, Fenton reaction-mediated ferroptosis is a transformative strategy that converts the intrinsic redox fragility of tumors into a therapeutic advantage, offering new directions for next-generation cancer treatment.