Single-Site Hydrogen-Bond Modulation Enhances Catalytic Ester Hydrolysis in a Zn(II)–TPA Scaffold

Zinc(II)-dependent metalloenzymes rely heavily on secondary-sphere interactions to modulate reactivity, inspiring the design of biomimetic Zn(II) catalysts that incorporate analogous features. Here, we introduce a hydroxymethyl-functionalized TPA ligand in which...