氧化应激
细胞生物学
活性氧
内质网
线粒体
生物能学
神经损伤
化学
生物物理学
渗透(HVAC)
未折叠蛋白反应
再生(生物学)
平衡
材料科学
炎症
氧化磷酸化
糖酵解
坐骨神经
胞浆
三磷酸腺苷
缺氧(环境)
周围神经
钙
细胞凋亡
周围神经损伤
作者
Xinyue Liang,Y. C. Song,Xianzhen Dong,Junwei Su,Yuanfang Huo,Junwei Yang,Zhiqiang LI,H-H Zhang,M Liu,Anfeng Yu,Honglian Dai
标识
DOI:10.1002/adma.202507931
摘要
ABSTRACT Due to the complex regenerative microenvironment, peripheral nerve repair poses significant challenges in clinical treatment. Severe injuries can lead to dysregulated iron homeostasis, and excessive iron produces reactive oxygen species (ROS) through the Fenton reaction. The subsequent oxidative stress further leads to mitochondrial and endoplasmic reticulum (ER) stress, which impedes nerve regeneration. In addition, insufficient vascular remodeling also limits the repair of damaged nerves. Herein, a poly(citric acid) (PCA)‐loaded gelatin‐lipoic acid (Gel‐LA) microgel hydrogel‐filled oriented electrospun fiber conduit was developed, which guides axonal alignment by topographical cues, promotes cellular infiltration and nutrient transport through a microgel cascade pore structure, and regulates the regenerative microenvironment via the ferrous ion (Fe 2+ ) chelation effect of PCA. The results demonstrate that this conduit effectively reduces the levels of Fe 2+ at the injury site, thereby alleviating mitochondrial and ER stress while promoting energy metabolism, vascular reconstruction, and nerve regeneration. This study highlights the potential of PCA in modulating the microenvironment of nerve injuries and provides new insights for developing tissue‐engineered scaffolds.
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