This article presents multi-response optimization of friction stir welding of dissimilar Al 6061-Titanium alloy using Taguchi based grey relational analysis. Taguchi’s L 9 orthogonal array was used for designing the experiments. Process parameters considered for the experiments were rotational speed, traverse speed and tilt angle. Ultimate tensile strength, yield strength, and % elongation were the responses measured which all are larger-the-better characteristics. Based on grey relational grade, optimum levels of process parameters were identified and further ANOVA analysis was carried out to find most significant process parameter.