The altered gut microbiota of high-purine-induced hyperuricemia rats and its correlation with hyperuricemia

肠道菌群 高尿酸血症 尿酸 生物 毛螺菌科 嘌呤 粪便 细菌 微生物学 厚壁菌 16S核糖体RNA 生物化学 遗传学
作者
Xiu Liu,Qiulan Lv,Hongyan Ren,Liu Gao,Peng Zhao,Xiaomin Yang,Guanpin Yang,Daxing Xu,Guangtao Wang,Wan Yang,Pengjun Wang,Zenglan Wang,Shichao Xing
出处
期刊:PeerJ [PeerJ, Inc.]
卷期号:8: e8664-e8664 被引量:66
标识
DOI:10.7717/peerj.8664
摘要

Some studies on the hyperuricemia (HUA) have focused on intestinal bacteria. To better understand the correlation between gut microbiota and HUA, we established a HUA rat model with high-purine diet, and used 16S rRNA genes sequencing to analyze gut microbiota changes in HUA rats. To analyze the potential role played by gut microbiota in HUA, we altered the gut microbiota of HUA rats with antibiotics, and compared the degree of uric acid elevation between HUA and antibiotic-fed HUA rats (Ab+HUA). Finally, we established a recipient rat model, in which we transplanted fecal microbiota of HUA and normal rats into recipient rats. Three weeks later, we compared the uric acid content of recipient rats. As a result, the diversity and abundance of the gut microbiota had changed in HUA rats. The Ab-fed HUA rats had significantly lower uric acid content compared to the HUA rats, and gut microbiota from HUA rats increased uric acid content of recipient rats. The genera Vallitalea, Christensenella and Insolitispirillum may associate with HUA. Our findings highlight the association between gut microbiota and HUA, and the potential role played by gut microbiota in HUA. We hope that this finding will promote the isolation and culture of HUA-related bacteria and orient HUA-related studies from being correlational to mechanistic. These steps will therefore make it possible for us to treat HUA using gut microbiota as the target.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
在水一方应助俊逸凌雪采纳,获得10
1秒前
科目三应助hans采纳,获得10
4秒前
CH发布了新的文献求助10
4秒前
5秒前
7秒前
狂野的研究僧完成签到,获得积分10
8秒前
lx发布了新的文献求助10
10秒前
赘婿应助CH采纳,获得10
12秒前
melody发布了新的文献求助10
13秒前
哇咔咔完成签到 ,获得积分10
16秒前
Hello应助狂野的研究僧采纳,获得10
17秒前
bkagyin应助Memory采纳,获得10
18秒前
ziji完成签到,获得积分10
19秒前
21秒前
mia005发布了新的文献求助30
22秒前
lianlian完成签到,获得积分10
22秒前
23秒前
26秒前
hans发布了新的文献求助10
27秒前
诚心的初露完成签到,获得积分10
27秒前
dennisysz发布了新的文献求助10
28秒前
连翘完成签到,获得积分10
29秒前
田様应助风吹似夏采纳,获得10
31秒前
豆子完成签到,获得积分10
32秒前
乐乐应助科研通管家采纳,获得30
33秒前
小二郎应助科研通管家采纳,获得10
33秒前
Owen应助科研通管家采纳,获得10
33秒前
情怀应助科研通管家采纳,获得10
33秒前
NexusExplorer应助科研通管家采纳,获得30
33秒前
wanci应助科研通管家采纳,获得10
34秒前
充电宝应助科研通管家采纳,获得10
34秒前
大模型应助科研通管家采纳,获得10
34秒前
34秒前
李白完成签到,获得积分10
42秒前
43秒前
NgiNgu完成签到 ,获得积分10
52秒前
orixero应助小元采纳,获得10
53秒前
JamesPei应助是否采纳,获得10
54秒前
科研通AI5应助SCI采纳,获得10
54秒前
彭于晏应助小梁采纳,获得10
55秒前
高分求助中
【此为提示信息,请勿应助】请按要求发布求助,避免被关 20000
ISCN 2024 – An International System for Human Cytogenomic Nomenclature (2024) 3000
Continuum Thermodynamics and Material Modelling 2000
Encyclopedia of Geology (2nd Edition) 2000
105th Edition CRC Handbook of Chemistry and Physics 1600
Maneuvering of a Damaged Navy Combatant 650
the MD Anderson Surgical Oncology Manual, Seventh Edition 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3777414
求助须知:如何正确求助?哪些是违规求助? 3322767
关于积分的说明 10211585
捐赠科研通 3038128
什么是DOI,文献DOI怎么找? 1667131
邀请新用户注册赠送积分活动 797971
科研通“疑难数据库(出版商)”最低求助积分说明 758103