化学
色谱法
质谱法
污染
气相色谱法
样品制备
气相色谱-质谱法
环境化学
生态学
生物
作者
Joseph K. Dzisam,Brian A. Logue
标识
DOI:10.1016/j.chroma.2019.460468
摘要
Nitrosoamines (NAs), including nitrosodipropylamine (NDPA), are highly toxic drinking water contaminants with minimum reporting levels (MRLs) in the parts-per-trillion range (0.2-20 ng/L). The quantification of NAs at these concentrations is extremely difficult, requiring both sophisticated instrumentation and laborious sample preparation procedures. An advanced sample preparation technique, ICE Concentration Linked with Extractive Stirrer (ICECLES), coupled with gas-chromatography mass-spectrometry, was used to analyze NDPA (MRL = 7 ng/L). ICECLES allowed ultratrace analysis of NDPA, producing an LOD of 0.2 ng/L, will below the MRL, and a linear range of 2-50 ng/L (using NDPA-d14 as an internal standard). Both inter- and intraassay precisions were ≤13%RSD, while the method accuracy was 100 ± 17.5%. The ICECLES method was applied to screen for possible NA contamination in selected drinking water sources. The concentration of NDPA in one drinking water source was 2.38 ± 0.34 ng/L and was detected (i.e., concentrations ≥ LOD), but was not quantifiable, in the other samples.
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