Targeted hyperthermia with plasmonic nanoparticles

From its beginnings, nanomedicine research has encountered several challenges that have slowed down its clinical translation. The first part of this chapter focuses on the targeted delivery of nanoparticles, examining their biodistribution and toxicity and how these factors have influenced progress in nanomedicine. In the second part of the chapter, the use of gold nanoparticles in photothermal therapy for cancer treatment is reviewed, from its conception to current status, with special emphasis on its limitations. The chapter summarizes by discussing the key areas needing improvement in order to move this promising therapy closer to the clinics.