Chimeric-antigen receptor T (CAR-T) cell therapy for solid tumor

Abstract Chimeric-antigen receptor T (CAR-T) cell therapy has been researched in the clinical. However, CAR-T cell therapy for solid tumor is faced with lots of challenges such as cytokine storm, how to find the specific antigen and limitation of microenvironment of tumor. In this review, we will discuss the research of CAR-T cell therapy for solid tumors of digestive system, and possible solutions and future direction.