细胞生物学
生物
麦格纳波特
转录因子
活性氧
激酶
磷酸化
RNA干扰
磷酸酶
蛋白激酶A
心理压抑
基因
遗传学
基因表达
核糖核酸
格里斯麦格纳波特
水稻
作者
Xinyu Liu,Qikun Zhou,Ziqian Guo,Peng Liu,Lingbo Shen,Ningli Chai,Bin Qian,Yongchao Cai,Wenya Wang,Ziyi Yin,Haifeng Zhang,Xiaobo Zheng,Zhengguang Zhang
出处
期刊:eLife
[eLife Sciences Publications, Ltd.]
日期:2020-12-04
卷期号:9
被引量:45
摘要
The production of reactive oxygen species (ROS) is a ubiquitous defense response in plants. Adapted pathogens evolved mechanisms to counteract the deleterious effects of host-derived ROS and promote infection. How plant pathogens regulate this elaborate response against ROS burst remains unclear. Using the rice blast fungus Magnaporthe oryzae , we uncovered a self-balancing circuit controlling response to ROS in planta and virulence. During infection, ROS induces phosphorylation of the high osmolarity glycerol pathway kinase MoOsm1 and its nuclear translocation. There, MoOsm1 phosphorylates transcription factor MoAtf1 and dissociates MoAtf1-MoTup1 complex. This releases MoTup1-mediated transcriptional repression on oxidoreduction-pathway genes and activates the transcription of MoPtp1/2 protein phosphatases. In turn, MoPtp1/2 dephosphorylate MoOsm1, restoring the circuit to its initial state. Balanced interactions among proteins centered on MoOsm1 provide a means to counter host-derived ROS. Our findings thereby reveal new insights into how M. oryzae utilizes a phosphor-regulatory circuitry to face plant immunity during infection.
科研通智能强力驱动
Strongly Powered by AbleSci AI