医学
类风湿性关节炎
胸腺瘤
血清学
免疫分型
发病机制
射线照相术
内科学
免疫系统
病理
免疫学
抗体
放射科
抗原
作者
Okinori Murata,Katsuya Suzuki,Hisatoshi Sugiura,Yasushi Kondo,Masaru Takeshita,Katsumi Koga,Maiko Takiguchi,Rina Kurisu,Yoshiaki Kassai,Hidekata Yasuoka,Kunihiro Yamaoka,Rimpei Morita,Akihiko Yoshimura,Tsutomu Takeuchi
出处
期刊:Rheumatology
[Oxford University Press]
日期:2021-02-16
卷期号:60 (12): 5595-5600
被引量:2
标识
DOI:10.1093/rheumatology/keab164
摘要
We sought to clarify the presence of radiographic thymus variants using a scoring system, and their association with clinical and immunological features in RA patients.A total of 387 RA patients were randomly selected from all patients visiting our department who underwent chest CT scanning, with exclusion of patients with thymoma or thymic cyst, or age < 30 years. Thymus size and attenuation score in axial CT images were quantitatively interpreted and assessed. Associations between immunophenotype data and clinical and serological features were analysed in a subset of patients.Thymic enlargement was found in 76 (19.6%) patients, and a thymus attenuation score ≥ 2 was found in 50 (12.9%) patients. The score was significantly associated with antibodies to ACPA positivity. Thymic enlargement was significantly associated with the proportions of CD4+ effector memory T cells.Radiographic thymus variants were frequently observed in RA patients and may reflect an abnormal immune response involved in the pathogenesis of RA.
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