High‐Throughput Measurement of log D and pK a

This chapter contains sections titled: Introduction Relationship between Ionization and Lipophilicity Measuring log D Shake-flask Method pH-metric Method Direct Chromatographic Methods Chromatographic Hydrophobicity Index (CHI) Microemulsion Electrokinetic Chromatography (MEEKC) Chromatography in the Presence of Octanol Reversed-Phase Chromatography Liquid–Liquid Partition Chromatography Measuring pKa Review of Methods The Effect of Co-solvents on pKa pH-Metric Titration Hybrid pH-Metric/UV Method Other Methods pH Gradient Titration Some Thoughts about High-throughput Analytical Chemistry