Levels of T-lymphocyte subsets and expression of MHC-II molecules on cells in tumor infiltrating lymphocytes from tumors of cattle

The present study on tumor infiltrating lymphocytes (TILs) from tumors of cattle has revealed 13% MHC-II+ve cells in TILs from horn cancer while those from nasal granuloma had 18% cells expressing MHC-II. In case of horn cancer, 54% TlLs were CD4+ve and 18% were CD8+ve whereas in case of nasal granuloma, 43% of TlLs were CD4+ve and 19% were CD8+ve. This indicates that TILs comprise mostly of T-cells with a predominance of helper cells in these tumors of cattle. The substantial percentage of MHC-ll+ve cells in TILs may indicate the presence of activated lymphocytes.