测试表
阿尔茨海默病
疾病
β淀粉样蛋白
淀粉样蛋白(真菌学)
BETA(编程语言)
肽
医学
神经科学
化学
病理
生物化学
生物
计算机科学
程序设计语言
作者
Sylvain Biéler,Claudio Soto
出处
期刊:Current Drug Targets
[Bentham Science]
日期:2004-08-01
卷期号:5 (6): 553-558
被引量:57
标识
DOI:10.2174/1389450043345290
摘要
A growing wealth of evidence indicates that the key pathological event in Alzheimer's disease is the conversion of the normal soluble amyloid-beta peptide into beta-sheet-rich oligomeric structures which have a neurotoxic activity and ability to form insoluble amyloid deposits that accumulate in the brain. Beta-sheet breakers constitute a new class of drugs that are designed to specifically bind amyloid-beta peptide and block and/or reverse this abnormal conformational change. In this article we review this approach, describe diverse compounds reported to have this activity and summarize the data supporting the view that beta-sheet breakers could be serious candidates to combat this devastating disease.
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