癌变
突变
结直肠癌
外显子
癌症研究
病理
生物
腺癌
基因
医学
癌症
遗传学
作者
Toshinari Minamoto,K. Sawaguchi,Masayoshi Mai,Naoyuki Yamashita,Takashi Sügimura,Hiroyasu Esumi
出处
期刊:PubMed
日期:1994-06-01
卷期号:54 (11): 2841-4
被引量:43
摘要
Clinicopathological evidence is accumulating that a superficial-type (flat) colorectal tumor is a distinct neoplastic entity. To clarify the genetic characteristics of this tumor, we investigated the K-ras gene mutations and morphological features of 43 tumors of this type. A mutation of the K-ras codon 12 was detected in only 5 (16%) of 31 adenomas and 2 (17%) of 12 adenocarcinomas. The presence or absence of this mutation was not correlated with the tumor size or stage or with histopathological findings. None of these tumors had a mutation in codon 13 or exon 2, including codon 61. This low incidence of K-ras mutations (16%) suggests that superficial-type colorectal tumors are etiologically distinct from ordinary colorectal polypoid tumors and that there may be an alternative pathway of colorectal tumorigenesis.
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