医学
破译
疾病
危险分层
多细胞生物
计算生物学
生物信息学
重症监护医学
细胞
病理
生物
遗传学
内科学
作者
Wesley Abplanalp,Nathan R. Tucker,Stefanie Dimmeler
标识
DOI:10.1093/eurheartj/ehac095
摘要
Abstract Cardiovascular disease remains the leading cause of death worldwide. A deeper understanding of the multicellular composition and molecular processes may help to identify novel therapeutic strategies. Single-cell technologies such as single-cell or single-nuclei RNA sequencing provide expression profiles of individual cells and allow for dissection of heterogeneity in tissue during health and disease. This review will summarize (i) how these novel technologies have become critical for delineating mechanistic drivers of cardiovascular disease, particularly, in humans and (ii) how they might serve as diagnostic tools for risk stratification or individualized therapy. The review will further discuss technical pitfalls and provide an overview of publicly available human and mouse data sets that can be used as a resource for research.
科研通智能强力驱动
Strongly Powered by AbleSci AI