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Efficiency of a biodegradable gel containing hyaluronic acid and berberine hydrochloride in endoscopic sinus surgery (ESS): A prospective comparative study

医学 外科 功能性内窥镜鼻窦手术 鼻内镜手术 透明质酸 可视模拟标度 麻醉 前瞻性队列研究 耳鼻咽喉科 内窥镜检查 鼻窦炎 解剖
作者
Nguyen Phi Long,Nghiem Duc Thuan,Do Lan Huong,Vu Van Minh,Bui Thanh Son,Quan Thanh Nam,Chu Thi Hong Ninh,Phạm Minh Tuấn,Nguyễn Anh Cường,Nguyen Van Thinh,Le Van Quan,Le T. Duong,Dinh Viet Hung,Nguyen Khanh,Pham Ngoc Thao
出处
期刊:American Journal of Otolaryngology [Elsevier]
卷期号:43 (3): 103397-103397 被引量:1
标识
DOI:10.1016/j.amjoto.2022.103397
摘要

To evaluate the efficiency of a biodegradable gel containing hyaluronic acid and berberine hydrochloride in endoscopic sinus surgery.Sixty-six chronic rhinosinusitis patients with or without nasal polyps who underwent bilateral endoscopic sinus surgery (ESS) were randomly received a biodegradable gel containing hyaluronic acid and berberine hydrochloride or merocel in both middle meatal spacers at the end procedure of ESS. Lund-Kennedy endoscopic score (LKES) was used to examine status of nasal cavity on preoperative day and postoperative day 1 to 7. The LKES ratio was calculated as the LKES on postoperative day divided into the LKES on preoperative day. Visual analogue score (VAS) was used to assess patient's status from the first postoperative day to the hospital discharge day. The average VAS during hospital stays was calculated by the sum of VAS in each examination day divided into the number of examined day. The LKES ratio, the average of VAS during hospital stays and length of hospitalized day of the patients were used as clinical outcome indices in early stage after surgery. A general linear model adjusted for confounding factors was used for data analysis.Adjusted mean of LKES ratio were lower in group used biodegrable gel of hyaruloic acid and berberin hydrochlode (study group) than those in merocele group in the postoperative day 1 to day 7. However, significant difference was found in the adjusted mean of LKES ratio on the postoperative day 2 to 6. Similarly, the adjusted mean of VAS during hospital stays and length of hospitalized day after surgery in study group were significantly decreased as compared with those in merocele group.Biodegradable material containing hyaluronic acid and berberine hydrochloride was more effective than merocel in length of hospital stay, post-operative symptoms, and sinus cavity's status in early stage after ESS.
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