Resveratrol may ameliorate rheumatoid arthritis via the STAT3/HIF‐1/VEGF molecular pathway

Rheumatoid arthritis (RA) is an autoimmune erosive disease leading to bone and cartilage destruction. It causes pain, inflammation, and swelling. Because of the severe adverse effects of chemical drugs, phytoremediation is taken to be considered nowadays. It is important to find out novel drug formulations and their mechanisms in rheumatoid arthritis to reduce patients suffering from this long-term disease. We suggest this hypothesis that Resveratrol (RSV) may act its anti-rheumatoid arthritis effects by STAT3/HIF-1/VEGF pathway for these reasons: (A) RSV exhibits anti-inflammatory properties, which can reduce inflammation of joints, (B) RSV reduces the level of pro-inflammatory cytokines accumulation, (C) RSV can suppress the expression of HIF-1 and VEGF genes and also inhibits STAT3 function. These molecules and their functions cause the disease progression of RA. Thus RSV can act as an anti-RA drug in this way, (D) According to previous findings, angiogenesis plays one of the main roles in RA and RSV inhibits angiogenesis via STAT3/HIF-1/VEGF pathway. By this explanation, RSV may perform its anti-RA function through this molecular pathway. PRACTICAL APPLICATIONS: Resveratrol (RSV) is a kind of stilbenoid that exhibits antioxidant, anti-inflammatory, and anti-angiogenesis activities by various molecular pathways. It exists in many plants like grapes, blueberries, etc. and it is the main component of red wine. It is a safe compound and it has beneficial effects on rheumatoid arthritis (RA). RSV decreases pain and helps ameliorate swollen joints which makes it a good candidate for RA patients, also it showed protective effects on osteoarthritis by reducing inflammation markers. We recommend the theory that RSV has therapeutic effects on RA via STAT3/HIF-1/VEGF molecular pathway and we investigate more information about it in this article. As this paper shows pharmacological and clinical documents about RSV in RA, it considers that RSV can ameliorate RA in STAT3/HIF-1/VEGF molecular pathway.