Goal setting is a common aspect of behavior modification, however, when goal setting is most successful is unknown. The objectives of this systematic review and meta-analysis were 1) to assess τhe literature on goal setting in businesses 2) to assess Locke’s theory of goal setting and 3) to analyze the practicality of this strategy for enhancing employee motivation and performance. An attempt is made to identify limiting conditions, moderator variables, and intriguing future study topics.