胰岛素抵抗
医学
胰岛素
机制(生物学)
糖尿病
内质网
炎症
内分泌学
内科学
骨骼肌
生物信息学
生物
细胞生物学
认识论
哲学
作者
Shin‐Hae Lee,Shi-Young Park,Cheol Soo Choi
标识
DOI:10.4093/dmj.2021.0280
摘要
Insulin resistance is the pivotal pathogenic component of many metabolic diseases, including type 2 diabetes mellitus, and is defined as a state of reduced responsiveness of insulin-targeting tissues to physiological levels of insulin. Although the underlying mechanism of insulin resistance is not fully understood, several credible theories have been proposed. In this review, we summarize the functions of insulin in glucose metabolism in typical metabolic tissues and describe the mechanisms proposed to underlie insulin resistance, that is, ectopic lipid accumulation in liver and skeletal muscle, endoplasmic reticulum stress, and inflammation. In addition, we suggest potential therapeutic strategies for addressing insulin resistance.
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