PI3K/AKT/mTOR通路
蛋白激酶B
细胞凋亡
MCF-7型
生物化学
氨基酸
生物
寡肽
抗氧化剂
信号转导
姜黄素
癌细胞
碳酸钙-2
肽
化学
体外
细胞生物学
癌症
人体乳房
遗传学
作者
Wei Wei,Xue‐Gong Fan,Shaohui Jia,Xiping Zhang,Zhao Zhang,Xuejun Zhang,Jiu-Xun Zhang,Ye-Wang Zhang
标识
DOI:10.3389/fnut.2021.763692
摘要
Sea cucumbers are one of many marine echinoderm animals that contain valuable nutrients and medicinal compounds. The bioactive substances in sea cucumbers make them have promising biological and pharmacological properties, including antioxidant, anti-bacterial, and anti-tumor effects. In this study, sea cucumber intestinal peptide (SCIP) is a small molecular oligopeptide (<1,000 Da) extracted from sea cucumber intestines hydrolyzed by alkaline protease. The analysis of amino acid composition showed that hydrophobic amino acids and branched-chain amino acids were rich in SCIP. Nowadays, although increasing studies have revealed the biological functions of the sea cucumber active substances, there are few studies on the function of SCIP. Furthermore, due to the anti-cancer activity being an essential characteristic of sea cucumber active substances, we also investigated the anti-cancer potential and the underlying mechanism of SCIP in vivo and in vitro. The results indicate that SCIP inhibits the growth of MCF-7 tumor cells in zebrafish and increases the apoptosis of human breast cancer MCF-7 cells. Further mechanism studies confirm that SCIP promotes the expression of apoptosis-related proteins and thus promotes the breast cancer cells (MCF-7) apoptosis via inhibition of PI3K/AKT signal transduction pathway.
科研通智能强力驱动
Strongly Powered by AbleSci AI