医学
免疫疗法
电流(流体)
CD47型
癌症研究
免疫学
免疫系统
电气工程
工程类
作者
Bing Tong,Mengzhao Wang
出处
期刊:Future Oncology
[Future Medicine]
日期:2018-09-01
卷期号:14 (21): 2179-2188
被引量:42
标识
DOI:10.2217/fon-2018-0035
摘要
Recently, many immunosuppressive checkpoints such as PD-L1, CTLA-4 and CD47, were identified in succession and serve as potential immunotherapy targets in human cancers. Among them, CD47, a ‘marker-of-self’ protein that is overexpressed broadly across tumor types, is emerging as a novel potent macrophage immune checkpoint for cancer immunotherapy. In this review, we highlight the prominent role of CD47 as a ‘don't-eat-me’ signal that inhibits macrophage phagocytosis for immune evasion of a tumor and presents the opportunities and challenges for CD47 inhibitors both as monotherapy and in combination treatments for hematological cancers and solid tumors; some of these agents are currently in clinical trials.
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