生物膜
细菌
粘附
化学
活性氧
微生物学
细胞粘附
三磷酸腺苷
细胞外
生物物理学
纳米技术
材料科学
胞外聚合物
细胞生物学
生物化学
生物
有机化学
遗传学
作者
H. Qiu,Fang Pu,Zhengwei Liu,Qingqing Deng,Panpan Sun,Jinsong Ren,Xiaogang Qu
出处
期刊:Small
[Wiley]
日期:2019-07-22
卷期号:15 (36)
被引量:77
标识
DOI:10.1002/smll.201902522
摘要
Abstract The formation of bacterial biofilm is one of the causes of antimicrobial resistance, often leading to persistent infections and a high fatality rate. Therefore, there is an urgent need to develop novel and effective strategies to inhibit biofilm formation. Adenosine triphosphate (ATP) plays an important role in bacterial adhesion and biofilm formation through stimulating cell lysis and extracellular DNA (eDNA) release. Herein, a simple and robust strategy for inhibiting biofilm formation is developed using CeO 2 ‐decorated porphyrin‐based metal‐organic frameworks (MOFs). The function of extracellular ATP (eATP) can be inhibited by CeO 2 nanoparticles, leading to the disruption of the initial adhesion of bacteria. Furthermore, planktonic bacteria can be killed by cytotoxic reactive oxygen species (ROS) generated by MOFs. As a consequence, the synergic effect of eATP deprivation and ROS generation presents excellent capacity to prevent biofilm formation, which may provide a new direction for designing flexible and effective biofilm‐inhibiting systems.
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