发光
镧系元素
纳米颗粒
材料科学
兴奋剂
检出限
光电子学
纳米技术
化学
离子
色谱法
有机化学
作者
Meiran Zhang,Wei Zheng,Yan Liu,Ping Huang,Zhongliang Gong,Jiaojiao Wei,Yu Gao,Shanyong Zhou,Xingjun Li,Xueyuan Chen
标识
DOI:10.1002/anie.201905040
摘要
Lanthanide (Ln3+ )-doped luminescent nanoparticles (NPs) with emission in the second near-infrared (NIR-II) biological window have shown great promise but their applications are currently limited by the low absorption efficiency of Ln3+ owing to the parity-forbidden 4f→4f electronic transition. Herein, we developed a strategy for the controlled synthesis of a new class of NIR-II luminescent nanoprobes based on Ce3+ /Er3+ and Ce3+ /Nd3+ co-doped CaS NPs, which can be effectively excited by using a low-cost blue light-emitting diode chip. Through sensitization by the allowed 4f→5d transition of Ce3+ , intense NIR-II luminescence from Er3+ and Nd3+ with quantum yields of 9.3 % and 7.7 % was achieved, respectively. By coating them with a layer of amphiphilic phospholipids, these NPs exhibit excellent stability in water and can be exploited as sensitive NIR-II luminescent nanoprobes for the accurate detection of an important disease biomarker, xanthine, with a detection limit of 32.0 nm.
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