Chemical Synthesis of Glycopeptides and Glycoproteins

In this chapter, recent progress in the chemical synthesis of glycoprotein is briefly summarized. Starting from the solid-phase synthesis of glycopeptide, the synthetic method for the glycosylated peptide thioester, which is the key intermediate for glycoprotein synthesis by the ligation method, is described. The results of several O- and N-linked glycoprotein syntheses are then exemplified to show the efficiency of the ligation method.