Based on biocompatible and stretchable hydrogels, Fei Li, Feng Xu, and co-workers propose a simple paradigm to prototype stretchable electronics with an embedded 3D helical conductive layout in article number 1801711. The 3D layout promises enhanced stretchability and robustness compared to traditional 1D and 2D designs. The hydrogel electronics can be directly incorporated onto the human body and perform as wearable pressure and strain sensors in a human-friendly manner.