体内
药物输送
内吞作用
透明质酸
化学
药理学
CD44细胞
细胞外
体外
阿霉素
靶向给药
癌症研究
细胞
生物化学
生物
医学
化疗
内科学
有机化学
生物技术
遗传学
作者
Hyuk Lee,Hongsuk Park,Gwang Jin Noh,Eun Seong Lee
标识
DOI:10.1016/j.carbpol.2018.08.141
摘要
pH-Responsive drug vehicles targeting the specific extracellular pH of tumors have served as potent tools to overcome the limitation (e.g., low tumor seletivity) in antitumor drug delivery system. Here, we describe the advantage of pH-responsive extracellular vesicles ([email protected]) containing the hyaluronic acid grafted with 3-(diethylamino)propylamine (HDEA) and a model antitumor drug, doxorubicin (DOX). We demonstrated their physicochemical characteristics through in vitro cell endocytosis, in vitro tumor cell toxicity, in vivo biodistribution, and in vivo tumor regression efficacy experiments. Because the [email protected] efficiently responded to extracellular tumor pH (pH 6.5) and actively bound to CD44 receptors on HCT-116 tumor cells, the EVs selectively inhibited CD44+ tumor cell growth in vitro, and CD44+ tumor development in vivo. From these results, we conclude that [email protected] can help in designing effective strategies for pharmacologic intervention in tumor therapy.
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