Synthesis of Heterohelicenes by a Catalytic Multi‐Component Povarov Reaction

A multi‐component Povarov reaction was used for the preparation of [4], [5] and [6]aza‐ and azaoxahetero helical‐shaped compounds. The oxidation of the tetrahydroquinolinic primary Povarov adducts to the aromatic quinolines is mandatory to achieve a helical‐shaped structure and can be carried out in a one‐pot fashion with DDQ. Resolution of [5] and [6]heterohelicenes was successfully performed by chiral HPLC.