脂联素
医学
基因型
单核苷酸多态性
内科学
胃肠病学
冠状动脉疾病
等位基因
限制性片段长度多态性
多态性(计算机科学)
基因多态性
基因
遗传学
生物
肥胖
胰岛素抵抗
作者
LI Song-sen,Xiaohua Niu,Guangjie Pan,Huili Chen
出处
期刊:Heart Surgery Forum
[Carden Jennings Publishing Co.]
日期:2018-08-13
卷期号:21 (5): E337-E340
被引量:2
摘要
This study aims to investigate the relationship between polymorphism of adiponectin (ADIPOQ) gene SNPS+276 and the severity of coronary heart disease (CHD) and coronary artery disease (CAD).A total of 582 inpatients were enrolled and divided into Group CHD (342 cases) and the control group (CON, 240 cases), according to their angiographic results from June 2014 to April 2016 for the genotype (G/T) analysis of ADIPOQ SNPs+276 by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).Group CHD: GG 110 (32%), GT 205 (59%), and TT27 (8%); Group CON: GG 36 (15%), GT 161 (67%), and TT 43 (18%) (P < .05). The frequency of allele G in group CHD was 62.1% and 48.5% in group CON (P < .05). The frequencies of genotype GG, GT, and TT were 67 (33.3%), 107 (53.2%), and 27 (13.5%), respectively, in the group with single vascular lesion, and 64 (45.4%), 53 (37.6%), and 24 (17%), respectively, in the group with multiple vascular lesions. There was statistical significance between the two groups (P < .05).The 276G gene of adiponectin may be a susceptibility gene of CHD, and the genotype GG may be related to the severity of this disease.
科研通智能强力驱动
Strongly Powered by AbleSci AI