效应器
生物
细胞生物学
C-C趋化因子受体7型
淋巴细胞生成
祖细胞
免疫学
祖细胞
细胞分化
干细胞
炎症
遗传学
趋化因子受体
趋化因子
基因
作者
Haiguang Wang,Kristin A. Hogquist
出处
期刊:eLife
[eLife Sciences Publications, Ltd.]
日期:2018-08-13
卷期号:7
被引量:76
摘要
The precise steps of iNKT subset differentiation in the thymus and periphery have been controversial. We demonstrate here that the small proportion of thymic iNKT and mucosal associated invariant T cells that express CCR7 represent a multi-potent progenitor pool that gives rise to effector subsets within the thymus. Using intra-thymic labeling, we also showed that CCR7+ iNKT cells emigrate from the thymus in a Klf2 dependent manner, and undergo further maturation after reaching the periphery. Ccr7 deficiency impaired differentiation of iNKT effector subsets and localization to the medulla. Parabiosis and intra-thymic transfer showed that thymic NKT1 and NKT17 were resident-they were not derived from and did not contribute to the peripheral pool. Finally, each thymic iNKT effector subset produces distinct factors that influence T cell development. Our findings demonstrate how the thymus is both a source of iNKT progenitors and a unique site of tissue dependent effector cell differentiation.
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