蓝藻
硅藻
乙酸乙酯
高效液相色谱法
细胞毒性
色谱法
衍生工具(金融)
生物活性化合物
生物
化学
立体化学
生物化学
植物
细菌
体外
经济
金融经济学
遗传学
作者
Hiroshi Nagai,Shingo Sato,Kaori Iida,Kazutaka Hayashi,Mioko Kawaguchi,Hajime Uchida,Masayuki Satake
出处
期刊:Toxins
[MDPI AG]
日期:2019-06-21
卷期号:11 (6): 366-366
被引量:25
标识
DOI:10.3390/toxins11060366
摘要
Cyanobacteria have been shown to produce a number of bioactive compounds, including toxins. Some bioactive compounds obtained from a marine cyanobacterium Moorea producens (formerly Lyngbya majuscula) have been recognized as drug leads; one of these compounds is aplysiatoxin. We have isolated various aplysiatoxin derivatives from a M. producens sample obtained from the Okinawan coastal area. The frozen sample was extracted with organic solvents. The ethyl acetate layer was obtained from the crude extracts via liquid-liquid partitioning, then separated by HPLC using a reversed-phase column. Finally, 1.1 mg of the compound was isolated. The chemical structure of the isolated compound was elucidated with spectroscopic methods, using HR-MS and 1D and 2D NMR techniques, and was revealed to be oscillatoxin I, a new member of the aplysiatoxin family. Oscillatoxin I showed cytotoxicity against the L1210 mouse lymphoma cell line and diatom growth-inhibition activity against the marine diatom Nitzschia amabilis.
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