Objective To explore the cause of anastomotic fistula after esophagus cancer and cardiac cancer operation and its prevention and treatment. Methods After excising the tumors,the esophagogastrostomy was performed in 60 cases,in which the cervial anastomose in 48 cases and intrathoracic anastomose was adopted in 12 cases.We retrospectively analyzed its prevention and treatment. Results Cervial anastomose in 48 cases,4 patients with anastomotic fistula in the died,while none of 12 cases in the cervial anastomose died.Conclusion Careful procedure and improving the anastomotic method are the key factors to reduce the anastomotic fistula,the accurate control of infection and full nutritive support are the effective methods to decrease the mortality rate of this disease.