Evaluation of Quality of Life of Non-small Cell Lung Cancer Patients Accepted Different Treatment Styles

Objective To investigate the influence of quality of life(QOL) of non-small cell lung cancer(NSCLC) patients by different combined styles of radiotherapy and chemotherapy. Methods Totally 151 patients with NSCLC were divided into three groups: concurrent chemo-radiotherapy group(n=43),sequential chemo-radiotherapy group(n=49) and chemotherapy only group(n=59).The QOL of patients were evaluated and analyzed by European Organization for Research and Treatment of Cancer′s Quality of Life Questionnaire-Core(EORTC QLQ-C30) before therapy,after therapy(4th week) and 1 month after therapy. Results The scores of QLQ were worse in role function,emotion function,social function,fatigue,vomiting,nausea,and constipation in the concurrent chemo-radiotherapy group and sequential chemo-radiotherapy group 1 day after therapy(P0.05),but the scores of QLQ were better in the two group 1 month after therapy(P0.05) In the chemotherapy only group,the score of QLQ was worse in social function 1 day and 1 month after therapy(P0.05);the scores of QLQ were better in vomiting,nausea,emotion function 1 month after therapy(P0.05);and there were no obvious changes in role function,fatigue,and constipation scores of QLQ 1 day and 1 month after therapy(P0.05).The score of QLQ was worse in body function in the concurrent chemo-radiotherapy group(P0.05) 1 day after therapy,but it was better in the sequential chemo-radiotherapy group(P0.05) 1 day after therapy.The score of QLQ was better in body function in the concurrent chemo-radiotherapy group(P0.05) 1 month after therapy(P0.05),but it was worse in the sequential chemo-radiotherapy group(P0.05) 1 month after therapy.The score of QLQ was better in total health situation in the concurrent chemo-radiotherapy group(P0.05) 1 month after therapy,but it was worse in the sequential chemo-radiotherapy group(P0.05),and it was of no significant change in the sequential chemo-radiotherapy group(P0.05).The score of QLQ was worse in economical situation in all the three group(P0.05) 1day after therapy and 1month after therapy. Conclusion Compared with the chemotherapy only and sequential chemo-radiotherapy,although the scores of QLQ could be worse in body function and role function were decreased,and the symptoms of fatigue,nausea and vomiting become worse 1 day after therapy,the concurrent chemo-radiotherapy can improve all the functions and symptoms after I mouth therapy,and the total health level was also be evidently increased.