Study on in vitro-in vivo correlation of erythromycin mkrocapsules using in vitro -in vivo correlation models

OBJECTIVE To evaluate the internal predictive ability of level A and B in vitro-in vivo correlation (IVIVC) models for eryth-romycin microcapsules. METHODS In vitro dissolution data of erythromycin microcapsules were collected for 12 h. Plasma concentration data were obtained from 6 rabbits after administration erythromycin microcapsules, in vitro absorption percentage was obtained by a deconvolu-tion-based level A model and compared with the in vitro dissolution. Further, basic and extended convolution level A IVIVC models were applied to investigate the in vitro-in vivo correlation of erythromycin microcapsules. Internal predictiveability of level A and level B was assessed by comparing observed and predicted plasma concentration data and by comparing in vitro dissolution time (MDT) and in vivo dissolution time (MRT). RESULTS Both A and B models can describe the in vitro-in vivo correlation. CONCLUSION Level A and B models have good internal predictiveability, and level A is better than level B.