Study on the biodegradation and biocompatibility of PLGA microspheres

OBJECTIVE To inspect the biodegradation and biocompatibility of the interferon-α PLGA microspheres.METHODS The degradation of PLGA microspheres in buffer solution in vitro was examined by optical microscope;Wistar rats were employed in this study.The biodegradation and biocompatibility in vivo were evaluated by the pathology slice.RESULTS In vitro the degradation percent of PLGA microspheres was over 80% in 6 weeks;and in vivo PLGA microspheres may be completely degraded in 6 weeks.Slight inflammatory reaction was observed at the part of injection,but pathologic influence was not seen.CONCLUSION The PLGA microspheres have good biodegradation and biocompatibility.