Establishment of rabbits hypertrophic scars model

Objective: To establish animal models for hypertrophic scars though creating wounds over the ventral surface of the rabbits′ ears. Methods: First, wounds were created over the ventral surface of the rabbits′ ears. on 7th day postwounding, the escha was removed. The histological changes were observed for 9 months. Results: After the inflammation, the formation of the granulation tissue, the ulcerated area epithelized step by step. On 30th day postwounding Visibly raised and palpable scars appeared, Each of the scars remained raising in 90 days or beyond, and remained the shapes on 270th day postwounding. Histologically, the scars on 90th day were noted to be thickened compared with surrounding tissue. The scars were demonstrated largely horizontally arranged collagen fibers, increased vascular tissue and mild chronic inflammation.The elevated area of the scars had irregular arranged collagen fibers, often with a circular or whirled appearance. There were also increased vascularity and proliferated fibroblasts on 180th and 270th day, the scars remained irregularly arranged collagen fibers and fibroblasts. Conclusion: Using the method of this experiment, animal models for HS could be easily replicated.