Effect of polygonum multiflorum and polygonum multiflorum preparation on immunoglobulin in rats

[Objective] To research the influence of polygonum multi.florum and polygonum multiflorum preparation on immunoglobulin in SD rats. [Methods] SD rats were divided into seven groups. Each group was administrated with drug,30g/kg a day orally for 90 d. The blood samples were taken on the 90 d for determination of serum IgG,IgM levels. [Results] Comparing control group and experimental groups after 60 d administration of polygonum multiflorum,polygonum multiflorum with high-dose hoelen group,polygonum mul-tiflorum with low-dose hoelen group,preparation polygoni multiflori,preparation polygoni multiflori with low-dose hoelen group the serum IgM levels were significantly elevated(P0.05),while the level after 90 d administration of polygonum multiflorum with high-dose hoelen group,polygonum multiflorum with low-dose hoelen group,preparation polygoni multiflori with high-dose hoelen group was significantly increased (P0. 05),the level of serum IgG,however,in group of polygonum multiflorum with low-dose hoelen group only after the 90 d administration was reduced. Between these groups they were statistically significant. [Conclusion] Administration of the polygonum multiflorum,preparation of polygonum multiflorum system for 60 or 90 d can induce a significant increase of serum IgM in rats,that can cause some liver damage.