血管生成素受体
淋巴管新生
血管生成素
淋巴系统
血管生成
受体酪氨酸激酶
生物
萌芽血管生成
淋巴管内皮
淋巴管
血管内皮生长因子C
细胞生物学
血管
内分泌学
血管内皮生长因子
内科学
癌症研究
血管内皮生长因子A
信号转导
免疫学
新生血管
医学
转移
癌症
血管内皮生长因子受体
出处
期刊:PubMed
日期:2010-06-01
卷期号:43 (2): 59-72
被引量:15
摘要
The angiopoietin/Tie system plays a key role in remodeling and maturation of blood vessels as well as lymphatic vessels. The angiopoietin family includes four ligands (Ang-1, Ang-2 and Ang-3/4) and two corresponding tyrosine kinase receptors (Tie1 and Tie2). The best characterized angiopoietins are Ang-1 and Ang-2. Ang-1 acts as an obligate agonist of the Tie2 receptor. Binding of Ang-1 to Tie2 induces its autophosphorylation and promotes vascular stability and integrity. Ang-1 induces lymphatic vessel enlargement, sprouting and proliferation in a VEGFR-3-dependent manner. In contrast, whether Ang-2 is agonistic or antagonistic is dependent on dose and context. Ang-2 modulates angiogenesis in a cooperative manner with another important angiogenic factor, vascular endothelial growth factor A. In the presence of VEGF-A, Ang-2 promotes vascular sprouting. When in the absence of VEGF-A, Ang-2 induces vascular regression. However, genetic studies have revealed that Ang-2-deficient mice exhibit more severe defects in the lymphatic vasculature than in blood vessels. Ang-2 seems to be involved in the remodeling and stabilization of lymphatic vessels. Although the Ang/Tie system is essential for blood and lymphatic vessel remodeling and maturation, defining its precise role in blood and lymphatic development has been a major challenge. This review provides an update on our current understanding of the angiopoietin/Tie system in lymphangiogenesis.
科研通智能强力驱动
Strongly Powered by AbleSci AI