亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Reconsidering Neuroprotection in the Reperfusion Era

医学 神经保护 冲程(发动机) 重症监护医学 内科学 机械工程 工程类
作者
Sean I. Savitz,Jean‐Claude Baron,Midori A. Yenari,Nerses Sanossian,Marc Fisher
出处
期刊:Stroke [Lippincott Williams & Wilkins]
卷期号:48 (12): 3413-3419 被引量:155
标识
DOI:10.1161/strokeaha.117.017283
摘要

Neuroprotection to prevent infarct progression as a potential treatment for acute ischemic stroke carries a long and disappointing history. The failures of these prior neuroprotection trials have many potential explanations that encompass both problems with the preclinical assessment of these drugs and the design/implementation of clinical trials.1 Prior development of neuroprotection has focused primarily on its use as a monotherapy, and no clinical trial was designed to determine whether neuroprotection could extend the time window for successful reperfusion or ameliorate the consequences of reperfusion. Acute stroke therapy has now entered the era of highly effective reperfusion with the recent publication of 5 positive thrombectomy trials.2 Combining neuroprotection with intravenous or intra-arterial reperfusion therapy is now an important next step in the development of acute stroke therapies. One approach to neuroprotection would be to initiate therapy early after ischemic stroke onset, either in the ambulance or at a primary stroke center/community hospital to potentially extend the time window for intravenous or intra-arterial therapy. A second approach would be to use neuroprotection during or after partial or complete reperfusion to reduce the consequences of reperfusion injury. Both future neuroprotective approaches will require preclinical studies that anticipate novel clinical trial designs and trials that will be organized and evaluated differently than past monotherapy neuroprotection trials. Acute ischemic stroke therapy is designed to reduce infarction of hypoperfused brain tissue and limit the expansion of already irreversibly injured tissue when treatment is initiated, leading to smaller infarction and improved clinical outcomes.3,4 Severely hypoperfused but still potentially viable ischemic brain represents the ischemic penumbra, whereas irreversibly injured tissue is the ischemic core.5 Early after stroke onset, most patients with a large vessel occlusion (LVO) have an extensive ischemic penumbra that can be salvaged by timely reperfusion. This concept was proven …
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
2秒前
充电宝应助科研通管家采纳,获得10
3秒前
OK应助科研通管家采纳,获得60
3秒前
英俊的铭应助科研通管家采纳,获得10
3秒前
7秒前
蝶步韶华发布了新的文献求助10
8秒前
tyj发布了新的文献求助10
12秒前
micor应助蝶步韶华采纳,获得10
13秒前
16秒前
Manbo发布了新的文献求助10
17秒前
蝶步韶华完成签到,获得积分10
19秒前
小山己几完成签到,获得积分10
21秒前
34秒前
jozz完成签到,获得积分10
43秒前
43秒前
50秒前
50秒前
dq发布了新的文献求助10
1分钟前
SciGPT应助yt采纳,获得10
1分钟前
英姑应助xwwx采纳,获得10
1分钟前
英姑应助totootwo采纳,获得10
1分钟前
1分钟前
1分钟前
totootwo发布了新的文献求助10
1分钟前
1分钟前
1分钟前
1分钟前
xwwx发布了新的文献求助10
1分钟前
1分钟前
wanci应助xwwx采纳,获得10
1分钟前
2分钟前
要减肥落雁完成签到,获得积分10
2分钟前
和风完成签到 ,获得积分10
2分钟前
orixero应助科研通管家采纳,获得10
2分钟前
2分钟前
Copyright应助科研通管家采纳,获得10
2分钟前
2分钟前
yanxueyi完成签到 ,获得积分10
2分钟前
xwwx发布了新的文献求助10
2分钟前
Hello应助totootwo采纳,获得10
2分钟前
高分求助中
(应助此贴封号)【重要!!请各用户(尤其是新用户)详细阅读】【科研通的精品贴汇总】 10000
《上海印钞厂志》 3000
2026年中国辛酸癸酸聚乙二醇甘油酯行业市场现状调查及投资机会研判报告 1000
2026年中国辛酸癸酸聚乙二醇甘油酯行业市场规模及竞争格局分析报告 1000
模型平均及其应用 900
Fundamentals of Pharmaceutical and Biologics Regulations: A Global Perspective, Second Edition 700
作者名:Kristopher P. Plain,悉尼大学的,目前只能查到其四篇论文,想找到其博士论文 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 纳米技术 工程类 有机化学 化学工程 生物化学 计算机科学 内科学 物理 复合材料 催化作用 细胞生物学 无机化学 光电子学 物理化学 电极 基因
热门帖子
关注 科研通微信公众号,转发送积分 7338296
求助须知:如何正确求助?哪些是违规求助? 8951757
关于积分的说明 18998371
捐赠科研通 6991001
什么是DOI,文献DOI怎么找? 3218334
关于科研通互助平台的介绍 2384136
邀请新用户注册赠送积分活动 2198276