生物
PI3K/AKT/mTOR通路
祖细胞
干细胞
自噬
细胞生物学
RPTOR公司
雷帕霉素的作用靶点
mTORC1型
祖细胞
癌症干细胞
信号转导
细胞凋亡
遗传学
作者
Delong Meng,Anderson R. Frank,Jenna L. Jewell
出处
期刊:Development
[The Company of Biologists]
日期:2018-01-01
卷期号:145 (1)
被引量:140
摘要
ABSTRACT The mammalian target of rapamycin (mTOR) senses nutrients and growth factors to coordinate cell growth, metabolism and autophagy. Extensive research has mapped the signaling pathways regulated by mTOR that are involved in human diseases, such as cancer, and in diabetes and ageing. Recently, however, new studies have demonstrated important roles for mTOR in promoting the differentiation of adult stem cells, driving the growth and proliferation of stem and progenitor cells, and dictating the differentiation program of multipotent stem cell populations. Here, we review these advances, providing an overview of mTOR signaling and its role in murine and human stem and progenitor cells.
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