Objective: To observe the effect of Zishen Yutai pill (ZYP) on embryo implantation rate in luteal phase of patients undergoing fertilization embryo transfer in vitro. Methods: One hundred and forty subjects were divided into two groups, they were all administered with human chorionic gonadotropin to improve the luteal function. To Group A, ZYP were given additionally for 6 g, three times a day for 14 consecutive days. Results: In Group A, mean serum progesterone, embryo implantation rate and clinical pregnancy rate was 15.42±1 91μg/L, 24 12% and 51.52% respectively, significantly higher than those in Group B, 13.92±1 96μg/L,16 67% and 34.78% (P0 001, P0 05 and P0 05). Conclusion: Oral administration of ZYP in luteal phase could raise the embryo implantation rate effectively.