表皮生长因子受体
肾脏疾病
调解人
表皮生长因子
肾
疾病
医学
癌症研究
病理生理学
受体
生物
内分泌学
内科学
出处
期刊:Cells
[MDPI AG]
日期:2022-10-28
卷期号:11 (21): 3416-3416
被引量:6
标识
DOI:10.3390/cells11213416
摘要
The epidermal growth factor receptor (EGFR) is expressed in numerous cell types in the adult mammalian kidney and is activated by a family of EGF-like ligands. EGFR activation has been implicated in a variety of physiologic and pathophysiologic functions. There is increasing evidence that aberrant EGFR activation is a mediator of progressive kidney injury in diabetic kidney disease. This review will highlight recent studies indicating its potential role and mechanisms of injury of both glomerular and tubular cells in development and progression of diabetic kidney disease.
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