线粒体
活性氧
程序性细胞死亡
细胞生物学
谷胱甘肽
功能(生物学)
癌细胞
氧化应激
GPX4
细胞内
生物
癌症
癌症研究
细胞凋亡
化学
生物化学
遗传学
酶
谷胱甘肽过氧化物酶
作者
Xiao Cheng,Jiale Zhang,Yunfeng Xiao,Zhihang Wang,Jia He,Meiling Ke,Sijie Liu,Qun Wang,Lei Zhang
标识
DOI:10.3390/ijms241210037
摘要
Ferroptosis, characterized by glutamate overload, glutathione depletion, and cysteine/cystine deprivation during iron- and oxidative-damage-dependent cell death, is a particular mode of regulated cell death. It is expected to effectively treat cancer through its tumor-suppressor function, as mitochondria are the intracellular energy factory and a binding site of reactive oxygen species production, closely related to ferroptosis. This review summarizes relevant research on the mechanisms of ferroptosis, highlights mitochondria's role in it, and collects and classifies the inducers of ferroptosis. A deeper understanding of the relationship between ferroptosis and mitochondrial function may provide new strategies for tumor treatment and drug development based on ferroptosis.
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