The local metabolism disturbance in chronic rhinosinusitis

Introduction Chronic rhinosinusitis (CRS) is a multifactorial and heterogeneous disorder of sinonasal mucosa. Based on the presence or absence of nasal polyps, CRS is classified into 2 clinical phenotypes, CRS with nasal polyps (CRSwNP) and CRS without nasal polyps (CRSsNP). CRSwNP can be further divided into eosinophilic (Eos CRSwNP) and noneosinophilic (Non-Eos CRSwNP) types according to eosinophil infiltration.