Nickel-Catalyzed Enantioconvergent Cycloadditions of Aziridines and Imines

Abstract We report asymmetric nickel-catalyzed cycloadditions of aziridines and imines enabled by a newly designed tyrosine-derived FOXAP ligand, delivering up to 97% ee and >20:1 dr. The reaction constructs imidazolidines bearing two nonadjacent stereocenters from racemic vinylaziridines and achiral imines in an enantioconvergent manner.