A comprehensive protocol for multiparametric brain MRI

The clinical utility of quantitative MRI (qMRI) techniques was demonstrated in numerous pathologies. This work investigated a range of qMRI pulse-sequences and processing methods with proven clinical applicability, aiming to establish a comprehensive and standard qMRI scan protocol for the brain. This multiparametric protocol provides a wide range of numeric maps (e.g., T1, T2, T2*, PD, M0, B1+, water and macromolecular fractions, susceptibility, mean diffusivity, and more) with whole-brain coverage, diverse set of clinical biomarkers, and the ability for stable longitudinal and multi-center investigations. Limitations and practical tips are provided for users interested in quantitative brain imaging.