神经退行性变
疾病
神经炎症
神经科学
基因组学
功能基因组学
帕金森病
阿尔茨海默病
医学
生物信息学
生物
基因组
遗传学
病理
基因
作者
Adriano Aguzzi,Martin Kampmann
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2023-09-08
卷期号:381 (6662)
被引量:1
标识
DOI:10.1126/science.adk5693
摘要
There are no cures for the most common neurodegenerative diseases. None of the currently approved treatments cure or halt these conditions; rather, they address symptoms or slow disease progression. A focus on protein deposits in the brain—a hallmark of Alzheimer’s disease (AD) and Parkinson’s disease (PD)—has led to the development of immunotherapy drugs. Other promising avenues of investigation include the roles of neuroinflammation in neurodegeneration. However, the clinical impact of these approaches is still uncertain. What about exploiting our knowledge of the human genome and the ability to modify it with surgically precise tools? Can functional genomics approaches in neurodegenerative disease research provide the breakthroughs we need?
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