Late-Stage Aryl C–H Bond Carboxylation with CO2 via Combining Metal-Free C–H Bond Borylation and ZnEt2-Promoted C–B Bond Carboxylation

A novel one-pot, two-step strategy for late-stage aryl ortho-C-H bond carboxylation of anilines with CO₂ has been developed. This methodology combines BBr₃-mediated aryl ortho-C-H bond borylation and ZnEt₂-promoted C-B bond carboxylation, enabling the efficient synthesis of diverse ortho-aminobenzoic acid derivatives. The protocol eliminates the requirement for precious metal catalysts and bulky non-labile directing groups, potentially serving as an efficient approach for installing a carboxylic acid group in functional molecules.